. Author manuscript; available in PMC: 2013 Aug 27.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2009 Nov 11;36(6):523–539. doi: 10.1007/s10928-009-9135-7

Table 4.

D-optimal designs for Model I with constraints

k_out (h⁻¹)	Sampling times
	λ = 0	λ = 0.75	λ = 1.5
0.3	0, 3.10, 10.5, 10.5 0,	4.80, 8.60, 11.0 0,	6.70, 6.70, 10.7
0.7	0, 1.45, 8.26, 8.26	0, 2.70, 6.42, 6.42 0,	4.20, 4.20, 6.60

Two doses, D = 100·V·IC₅₀ and D = 10·V·IC₅₀, are used with the same sampling times. The parameter values used were k_el = 0.3 h⁻¹, V = 90 l, k_in = 9 units/h, I_max = 1, and IC₅₀ = 100 ng/ml. Only the D-optimal sampling times are listed. Every D-optimal design presented in the table consists of 8 dose–time pairs, obtained by combining each of the two doses, 100·V·IC₅₀ and 10·V·IC₅₀, with each of the 4 sampling times given in the table