. Author manuscript; available in PMC: 2013 Aug 27.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2009 Nov 11;36(6):523–539. doi: 10.1007/s10928-009-9135-7

Table 5.

D-optimal designs for Model I with constraints

k_out (h⁻¹)	λ = 0	λ = 0.75	λ = 1.5
0.3	6.70	15.5	29.0
	0, 3.10, 10.1, 10.1 0,	4.80, 10.0, 10.0	0, 6.30, 9.10, 10.9
0.7	100	100	100
	0, 1.36, 6.8, 17.0	0, 2.76, 6.3, 13.8	0.28, 3.9, 6.24, 10.2

Any two doses each not exceeding 100·V·IC₅₀ are permitted. The same sampling times are used with each of the two doses. The lowest dose expressed in units of V·IC₅₀ and the 4 optimal sampling times are listed. The highest feasible dose of 100·V·IC₅₀ is used in all of these designs. Every D-optimal design consists of 8 dose–time pairs obtained by combining each of the two doses, 100·V·IC₅₀ and the given dose with each of the 4 indicated sampling times