Table 7.

D-efficiencies for some 8-point designs for Model I

kout(h−1)	Study design
	A1	B1	C1	D1	E1	F1	G1	H1	I1	K1	L1	M1
0.3	0.89	0.90	0.41	0.69	0.76	0.84	0.56	0.67	0.18	0.44	0.28	1.0
0.7	0.96	1.0	0.16	0.45	0.76	1.0	0.49	0.73	0.07	0.35	0.45	1.0

The parameter values used were k_el = 0.3 h⁻¹, V = 90 l, k_in = 9 units/h, I_max = 1, and IC₅₀ = 100 ng/ml.

The designs A1–M1 are given in Table 6