Table 2.

Names and sequences of COL1A1 and COL1A2 3'UTR indel targeting siRNAs

Name	Target	Sequence	Strand
si_A1_i	COL1A1 allele carrying an insertion	GAAGGGCCAAGCACGACAAuu	Sense strand
		ucCUUCCCGGUUCGUGCUGUU	Anti sense strand
si_A1_ni	COL1A1 allele not carrying an insertion	GAAGGGCCACGACAAAGCAuu	Sense strand
		uuCUUCCCGGUGCUGUUUCGU	Anti sense strand
si_A2_i	COL1A2 allele carrying an insertion	CCCAAAGUUGUCCUCUUCUuu	Sense strand
		gcGGGUUUCAACAGGAGAAGA	Anti sense strand
si_A2_ni	COL1A2 allele not Carrying an insertion	CCCAAAUCUUCUUCAGAUUuu	Sense strand
		acGGGUUUAGAAGAAGUCUAA	Anti sense strand

Four siRNAs were designed to target the region surrounding the four base pair indel rs3840870 in COL1A1 and the seven base pair indel rs3917 in COL1A2. One siRNA was created to target each allele of a heterozygous individual. Each strand had a two-nucleotide 3'-overhang, indicated by lower-case letters. Denotation, sense and active anti sense strand for each siRNA are displayed in the table.