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Relationship between the phenotype determined by in vitro drug sensitivity assays, expressed as IC50 of CQ, and the pfcrt genotype, defined by either the absence of mutations (wild type) or presence of point mutations. Here, different genotypes are classified as K76, T76, and K+T76. The solid line (corresponding to 100 nM CQ; highly resistant) hypothetically shows the resistance levels for in vitro CQ resistance.
