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. 2013 May 1;88(5):828–834. doi: 10.4269/ajtmh.11-0795

Figure 2.

Figure 2.

Relationship between in vitro IC50 values of CQ and pfmdr-I genotypes, defined by either the absence of mutations (wild type) or presence of point mutations. Here, different genotype are classified as NND (N86, N1042, D1246), NNY (N86, N1042, Y1246), YND (Y86, N1042, D1246), YDD (Y86, D1042, D1246), YNY (Y86, N1042, Y1246), YDY (Y86, D1042, Y1246), YNY+D (Y86, N1042, Y+D1246), NDY+D (N86, D1042, Y+D1246), N+YNY+D (N+Y86, N1042, Y+D1246), YDY+D (Y86, D1042, Y+D1246), and YN+DY (Y86, N+D1042, Y1246). The solid line (corresponding to 100 nM; highly resistant) hypothetically shows the resistance levels for in vitro CQ resistance.