Table 1.
Family history associations using four different family history scores and statistical comparison of the family history score methods
| Disorder | Associations using different family history scoresa
|
Statistical comparisonsb
|
|||||
|---|---|---|---|---|---|---|---|
| Dichotomous score | Density scores
|
Density scores v. dichotomous score | Proportion score v. observed score | Reed’s score v. observed score | |||
| Observed | Proportion | Reed’s scorec | |||||
| Major depressive episode | 1.40*** (1.21–1.62) | 1.42*** (1.24–1.63) | 1.42*** (1.24–1.63) | 1.43*** (1.25–1.64) | 1.02 (0.91–1.14) | 1.00 (0.95–1.06) | 1.01 (0.96–1.05) |
| Anxiety | 1.45*** (1.27–1.66) | 1.47*** (1.29–1.69) | 1.47*** (1.29–1.68) | 1.45*** (1.27–1.66) | 1.01 (0.92–1.11) | 1.00 (0.95–1.05) | 0.99 (0.95–1.02) |
| Suicide attempt | 1.31** (1.07–1.62) | 1.37** (1.14–1.66) | 1.29** (1.07–1.56) | 1.30** (1.07–1.59) | 1.01 (0.91–1.11) | 0.94 (0.88–1.01) | 0.95* (0.90–1.00) |
| Schizophreniform disorder | 1.45* (1.09–1.94) | 1.49** (1.17–1.91) | 1.45** (1.16–1.81) | 1.49** (1.17–1.89) | 1.01 (0.86–1.19) | 0.97 (0.86–1.10) | 1.00 (0.95–1.05) |
| Conduct disorder | 1.43*** (1.22–1.68) | 1.79*** (1.54–2.08) | 1.80*** (1.55–2.09) | 1.76*** (1.51–2.05) | 1.24*** (1.12–1.38) | 1.00 (0.95–1.06) | 0.98 (0.93–1.04) |
| Alcohol dependence | 1.21** (1.05–1.40) | 1.46*** (1.27–1.69) | 1.44*** (1.25–1.66) | 1.46*** (1.27–1.68) | 1.20*** (1.11–1.30) | 0.99 (0.93–1.04) | 1.00 (0.96–1.04) |
| Drug dependence | 1.28** (1.09–1.50) | 1.38*** (1.19–1.60) | 1.36*** (1.17–1.58) | 1.34*** (1.16–1.56) | 1.06 (0.97–1.16) | 0.99 (0.95–1.03) | 0.98 (0.92–1.04) |
| Ever smoked | 1.26** (1.07–1.47) | 1.51*** (1.32–1.72) | 1.67*** (1.46–1.92) | 1.65*** (1.44–1.89) | 1.28** (1.08–1.53) | 1.11* (1.02–1.21) | 1.09* (1.01–1.18) |
| Asthma | 1.20* (1.04–1.39) | 1.29*** (1.12–1.48) | 1.31*** (1.14–1.51) | 1.32*** (1.14–1.52) | 1.09 (0.99–1.19) | 1.02 (0.98–1.06) | 1.02 (0.98–1.06) |
a
Sex-adjusted odds (95% confidence intervals) of the proband having the disorder associated with a 1 standard deviation change in the family history score for that disorder (family history scores have been z-standardized).
b
Statistical comparison of the family history score methods. Odds ratios (95% confidence intervals) for tests of whether the associations between family history and disorder differ for different family history score methods.
*
p<0.05,
**
p<0.01,
***
p<0.001.