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. Author manuscript; available in PMC: 2013 Aug 27.
Published in final edited form as: Differentiation. 2011 Mar 17;81(4):233–242. doi: 10.1016/j.diff.2011.02.005

Figure 1.

Figure 1

1 activates neuronal genes in Ink4a/Arf-/-; PTEN-/-; EGFRvIII astrocytes (SS05 cells). (A) Chemical structure of lead isoxazole (1). (B) 1 induces a concentration-dependent increase in both GluR2- and NR1-luciferase (luc) reporters. (C-D) 1 promotes neuronal gene expression (Tuj 1) in SS05 cells compared to vehicle control (DMSO) in 4-day cultures. (E-F) 1 blocks proliferation of SS05 cells, compared to vehicle control (DMSO) in 4-day cultures. Scale bar: 25 μm. (G) Quantification of Ki67+ and Tuj1+ cells after 4 days of vehicle or 1 treatment is shown. (**p < 0.001, t-test, data in graphs represent ± s.d. from three independent experiments).