Table 1.
Outcomes of drug dosing*
| Daily dose (mg/kg/day) | Days of dosing | Total dose (mg/kg) | Drug route | No. of animal | G6PD activity (% of WT) | Death | CNS toxicity | Hemolysis |
|---|---|---|---|---|---|---|---|---|
| Primaquine | ||||||||
| 57† | 1 | 57 | i.p. | 3 | 14.9 ± 1.3 | 3 | 0 | 0 |
| 42.5‡ | 1 | 42.5 | i.p. | 8 | 14.8 ± 1.1 | 4 | 4 | 4 |
| 42.5† | 1 | 42.5 | i.p. | 8 | 15.0 ± 1.2 | 0 | 0 | 8 |
| 42.5† | 3 | 127.5 | i.p. | 8 | 14.5 ± 1.4 | 2 | 2 | 6 |
| 28.5† | 7 | 200 | p.o. | 8 | 14.9 ± 1.2 | 0 | 0 | 8 |
| 28.5† | 7 | 200 | p.o. | 7 | 15.0 ± 1.7 | 0 | 0 | 7 |
| 25‡ | 5 | 125 | p.o. | 5 | 14.8 ± 1.6 | 0 | 0 | 5 |
| 17.5‡ | 5 | 87.5 | p.o. | 5 | 15.0 ± 1.7 | 0 | 0 | 5 |
| 15‡ | 5 | 75 | p.o. | 5 | 14.7 ± 1.4 | 0 | 0 | 5 |
| 8.75‡ | 5 | 43.75 | p.o. | 5 | 14.3 ± 1.2 | 0 | 0 | 5 |
| 4.375‡ | 5 | 21.9 | 5 | 14.8 ± 1.8 | 0 | 0 | 2 | |
| Pamaquine | ||||||||
| 14‡ | 5 | 70 | p.o. | 5 | 14.9 ± 1.5 | 0 | 0 | 5 |
| Chloroquine | ||||||||
| 25‡ | 7 | 175 | p.o. | 8 | 14.5 ± 1.2 | 0 | 0 | 0 |
| 60‡ | 5 | 300 | p.o. | 5 | 14.7 ± 1.7 | 0 | 0 | 0 |
| Mefloquine | ||||||||
| 117‡ | 2 | 234 | p.o. | 5 | 14.5 ± 1.4 | 0 | 0 | 0 |
*
WT = wild-type; CNS = central nervous system. Values are mean ± SE.
†
Daily dose was spited to two with 6 hours apart.
‡
Single dosing.
CNS toxicities were displayed by a characteristic seizure pattern and decreased spontaneous motor activity.