Table 3.

Hemolytic effects of pamaquine in G6PDD mice

Daily dose (mg/kg/d)	14
Regimens	Split doses
Days of dosing	5
Total dose (mg/kg)	70
Route	p.o.
G6PD activity (% of wild-type)	14.9 ± 1.5
	Day
	0	7
RBC (106/μL)	9.9 ± 0.3	3.3 ± 0.7*
HCT (%)	53.6 ± 1.6	16.7 ± 4.7*
Hb (g/dL)	11.8 ± 0.7	6.1 ± 0.8*
Haptoglobin (μg/mL)	41 ± 20	25.5 ± 17*
Reticulocyte (% of RBC)	2.7 ± 0.2	6.5 ± 0.3*
Heinz body (% of RBC)	0.0 ± 0.0	13.5 ± 1.2*

Values are mean ± SE. RBC = red blood cell; HCT = hematocrit; Hb = hemoglobin.

^*P < 0.01 (Day 7 vs. Day 0).