Table 5.
Hemolytic Index of tested drugs administered p.o.
| Drug | Daily dose (mmol/kg/d) | Total dose (mmol/kg) | % RBC loss* | %Hemolysis | Hemolytic index† |
|---|---|---|---|---|---|
| Primaquine | 0.1 | 0.5 | 32.25 ± 11 | 161 | |
| 0.067 | 0.335 | 21.21 ± 8 | 106 | ||
| 0.058‡ | 0.29 | 20.02 ± 6 | 100 | 1 | |
| 0.0335 | 0.168 | 14.43 ± 11 | 72 | ||
| 0.0168 | 0.084 | 12.5 ± 1 | 63 | ||
| Pamaquine | 0.044 | 0.22 | 66.67 ± 7.0 | 333 | 6.6 |
| Chloroquine | 0.188 | 0.94 | 1.0 ± 0.1 | 0.05 | 0.0003 |
| Mefloquine | 0.31 | 0.62 | 0.2 ± 0.01 | 0.01 | 0.0001 |
| Tafenoquine | 0.0286 | 0.086 | 4.3 ± 0.2 | 21.5 | 0.67 |
*
Values are mean ± SE.
†
The reduction in the red blood cell (RBC) count after administration of primaquine given at 0.29 mmol/kg (15 mg/kg/day, the causal prophylactic ED100 dose), was set as 100% hemolysis on the standard curve. All other values of the reduction in the RBC were normalized against this value. The Hemolytic Index (HI) value was calculated by dividing the percentage of hemolysis with a test drug by the percentage of hemolysis with an equimolar dose of primaquine.
‡
A 100% effective causal prophylactic dose (CP ED100) in Imprinting Control Region (ICR) mouse Plasmodium berghei sporozoite challenge mode.