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. Author manuscript; available in PMC: 2013 Aug 27.
Published in final edited form as: Neurosci Lett. 2006 Jun 12;403(0):162–165. doi: 10.1016/j.neulet.2006.04.065

Fig. 2.

Fig. 2

Oligomeric-Aβ1–42 decreases AP number and increases AHP amplitude: (A) representative records of AP evoked by current injection (150 pA, 1 s). Bath application of Aβ (Panel A1, top) but not vehicle (Panel A2, top) is associated with a decrease in AP number compared with control ACSF. Insets below these tracings show, respectively, expanded detail for spike number 13 in both control and Aβ (A1) and for spike number 19 in both control and vehicle conditions (A2) to demonstrate that Aβ increases AHP amplitude whereas vehicle does not; (B) summary plots of AP number versus delay from onset of current injection. Wash in of Aβ decreases the number of AP (left panels) whereas vehicle wash in has no effect on AP number (right panels); and (C) summary graphs of AHP changes as a function of control AHP amplitude. Wash in of Aβ (filled bars) significantly increases the mean AHP amplitude, whereas vehicle wash in (open bars) has no effect. *p<0.01 (oligomer vs. control).