. Author manuscript; available in PMC: 2013 Aug 27.

Published in final edited form as: Cancer Causes Control. 2010 Dec 25;22(3):437–447. doi: 10.1007/s10552-010-9715-2

Table 4. Association of LINE-1 and Alu methylation with cancer mortality.

Methylation	Person-years	All cancers		Prostate cancer		Lung cancer		Colorectal cancer		Other cancers

		No.	HR (95% CI)^a	No.	HR (95% CI)^a	No.	HR (95% CI)^a	No.	HR (95% CI)^a	No.	HR (95% CI)^a
LINE-1 (%5mC)
Quartile^b
Q4 (86.2-78.5)	1,287	3	Ref.	0	Ref.	0	Ref.	0	Ref.	3	Ref.
Q3 (78.4-77.2)	1,207	3	1.0 (0.2-4.8)	1	N/A	1	N/A	0	N/A	1	0.3 (0.03-3.3)
Q2 (77.1-75.9)	1,298	11	3.3 (0.9-11.9)	1	N/A	3	N/A	1	N/A	6	1.9 (0.5-7.7)
Q1 (75.8-68.1)	1,230	10	2.9 (0.8-10.7)	3	N/A	0	N/A	1	N/A	6	1.6 (0.4-6.6)
			P-trend=0.031		P-trend=0.093		P-trend=0.598		P-trend=0.250		P-trend=0.232
Median^b
High (86.2-77.2)	2,494	6	Ref.	1	Ref.	1	Ref.	0	Ref.	4	Ref.
Low (77.1-68.1)	2,528	21	3.2 (1.3-7.9)	4	4.5 (0.5-41.5)	3	4.0 (0.3-47.6)	2	N/A	12	2.6 (0.8-8.1)
Alu (%5mC)
Quartile^b
Q4 (32.4-26.8)	1,355	4	Ref.	1	Ref.	0	Ref.	0	Ref.	3	Ref.
Q3 (26.7-26.1)	1,149	4	1.2 (0.3-4.9)	0	N/A	2	N/A	0	N/A	2	0.8 (0.1-4.8)
Q2 (26.0-25.6)	1,245	12	3.4 (1.1-10.9)	2	2.0 (0.2-23.3)	2	N/A	1	N/A	7	2.5 (0.6-10.0)
Q1 (25.5-23.0)	1,323	8	2.1 (0.6-7.2)	2	1.4 (0.1-16.7)	0	N/A	1	N/A	5	1.6 (0.4-7.0)
			P-trend=0.103		P-trend=0.504		P-trend=0.671		P-trend=0.226		P-trend=0.285
Median^b
High (32.4-26.1)	2,504	8	Ref.	1	Ref.	2	Ref.	0	Ref.	5	Ref.
Low (26.0-23.0)	2,568	20	2.5 (1.1-5.8)	4	3.3 (0.4-30.5)	2	1.5 (0.2-12.1)	2	N/A	12	2.3 (0.8-6.6)

%5mC percentage of 5-methyl cytosine, CI confidence interval, HR hazard ratio, N/A not available

Adjusted by age, BMI, race, education, smoking, pack-years, and alcohol drinking

The quartiles and the medians of LINE-1 or Alu measures were based on values among subjects free of baseline cancers