TABLE 3.
In vitro interaction between ITZ and NIFa
| Strain | MIC (μg/ml) alone
|
Result according to theory
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| LA
|
BI (nonparametric)
|
||||||||
| MIC (μg/ml) in combination
|
Result
|
||||||||
| ITZ | NIF | ITZ | NIF | FICI | INT | ΣSYN (n) | ΣANT (n) | INT | |
| V09-22 | 0.25 | 10 | 0.12 | 1.2 | 0.6 | NI | 511 (15) | −21.5 (7) | SYN |
| V09-23 | 0.25 | 20 | 0.03 | 5 | 0.35 | SYN | 45.3 (19) | −9.2 (4) | NI |
| AZN5161 | 0.12 | 10 | 0.03 | 5 | 0.75 | NI | 60.6 (12) | −25.7 (1) | NI |
| AZN7820 | 0.25 | 5 | 0.06 | 1.25 | 0.50 | SYN | 321.6 (11) | −62.9 (8) | SYN |
| AZN8248 | 0.25 | 10 | 0.06 | 2.5 | 0.50 | SYN | 232 (27) | −10.8 (3) | SYN |
| AZN9339 | 0.25 | 10 | 0.12 | 2.5 | 0.75 | NI | 45.3 (12) | 0 (0) | NI |
| AZN9362 | 0.25 | 20 | 0.03 | 2.5 | 0.25 | SYN | 42.2 (30) | −6.9 (10) | NI |
| Median | 0.25 | 10 | 0.5 | 60.6 | −10.8 | ||||
| V09-18 | 32 | 10 | 1 | 1.2 | 0.15 | SYN | 218 (35) | −21.2 (1) | SYN |
| V09-19 | 32 | 10 | 1 | 1.2 | 0.15 | SYN | 219 (13) | 0 (0) | SYN |
| AZN5241 | 32 | 10 | 1 | 2.5 | 0.28 | SYN | 552 (24) | −66.7 (3) | SYN |
| AZN5242 | 32 | 80 | 1 | 2.5 | 0.06 | SYN | 1050 (18) | 0 (0) | SYN |
| AZN7720 | 16 | 80 | 0.25 | 10 | 0.14 | SYN | 134 (41) | −1.5 (1) | SYN |
| AZN7722 | 32 | 10 | 1 | 1.2 | 0.15 | SYN | 1,114 (38) | −72.6 (5) | SYN |
| AZG7 | 32 | 20 | 1 | 2.5 | 0.16 | SYN | 272 (14) | −16.9 (3) | SYN |
| Median | 32 | 10 | 0.15 | 272 | −16.9 | ||||
a
Abbreviations: LA, Loewe additivity; INT, interpretation; NI, no interaction; SYN, synergism; ANT, antagonism; n, number of interactions.