TABLE 1.
MICs of β-lactams for clinical strain AJC68081, E. coli TG1, E. coli TG1 (pBE-1), and E. coli TG1 (pGER1)
Antibiotic | MIC (μg/ml)a
|
|||
---|---|---|---|---|
AJC68081 (produces AmpC of AG3) | E. coli TG1 | E. coli TG1 (pBE-1)b | E. coli TG1 (pGER1)c | |
Amoxicillin | >256 | 3 | 256 | 128 |
Amoxicillin + clavulanated | 6 | 2 | 24 | 32 |
Piperacillin | >256 | 0.38 | 64 | 8 |
Cephalothin | >256 | 3 | >256 | >256 |
Cefuroxime | >256 | 1.5 | >256 | >256 |
Cefoxitin | >256 | 2 | 128 | 2 |
Cefotaxime | 256 | 0.023 | 2 | 4 |
Cefotaxime + clavulanated | 0.19 | 0.023 | 1 | 1 |
Ceftazidime | 32 | 0.064 | 0.75 | 16 |
Ceftazidime + clavulanated | 0.19 | 0.064 | 0.5 | 8 |
Cefepime | 32 | 0.016 | 0.047 | 0.25 |
Aztreonam | 12 | 0.032 | 0.25 | 1 |
Imipenem | 1 | 0.125 | 0.38 | 0.125 |
Meropenem | 0.75 | 0.008 | 0.023 | 0.012 |
Clavulanic acid | 8-16 | ND | ND | ND |
Sulbactam | 16-32 | ND | ND | ND |
ND, not done.
Transformant producing AmpC β-lactamase of AG3.
Transformant producing AmpC β-lactamase of A. baumannii.
Clavulanate was used at 4 μg/ml.