TABLE 3.

Affinities of PIP, CTX, and CRO to H. influenzae ATCC 33391 and BLNAR I-1053 PBPs

Strain	Antimicrobial agent	MICa (μg/ml)	IC50 (μM) for PBP:
			1a	1b	2	3a	3b
ATCC 33391	PIP	0.0313	>100	47	2.3	0.34	0.18
	CTX	0.0078	80	11	>100	0.15	0.19
	CRO	0.002	33	10	>100	0.08	0.04
I-1053	PIP	0.0625	>100	71	3.4	NDb	ND
	CTX	2	86	20	>100	ND	ND
	CRO	0.25	16	19	97	ND	ND

^aMICs were determined by the broth microdilution method.

^bND, not detected.