Table 1.
Baseline characteristics of participants free of CKD at ARIC visit 1 (1987–1989) overall and by number of APOL1 risk alleles
| Characteristic | Overall Sample (n=3067) | Zero or One APOL1 Risk Allele (n=2663) | Two APOL1 Risk Alleles (n=404) | P Value Comparing Two with Zero or One Allele |
|---|---|---|---|---|
| Age (yr) | 53.2±5.8 | 53.3±5.8 | 52.7±5.6 | 0.04 |
| Women, n (%) | 1927 (62.8) | 1669 (62.7) | 258 (63.9) | 0.65 |
| Study center, n (%) | 0.41 | |||
| Forsyth County, NC | 328 (10.7) | 280 (10.5) | 48 (11.9) | |
| Jackson, MS | 2739 (89.3) | 2383 (89.5) | 356 (88.1) | |
| Hypertension, n (%) | 1644 (53.6) | 1415 (53.1) | 229 (56.7) | 0.18 |
| Systolic BP (mmHg) | 127±20 | 127±20 | 128±20 | 0.43 |
| Diastolic BP (mmHg) | 80±12 | 79±12 | 80±12 | 0.08 |
| Hypertension medication use, n (%) | 1189 (38.8) | 1025 (38.5) | 164 (40.6) | 0.30 |
| Fasting blood glucose (mg/dl)a | 111±42 | 111±42 | 110±38 | 0.52 |
| Diabetes, n (%) | 536 (17.5) | 458 (17.2) | 78 (19.3) | |
| Body mass index (kg/m2)b | 29.6±6.1 | 29.5±6.1 | 30.0±6.1 | 0.20 |
| Total cholesterol (mg/dl) | 215±45 | 215±44 | 212±49 | 0.29 |
| HDL cholesterol (mg/l)c | 55±18 | 55±18 | 56±19 | 0.43 |
| eGFR (ml/min per 1.73 m2) | 104.6±16.7 | 104.7±16.6 | 104.5±17.2 | 0.89 |
| Global ancestry (% European ancestry)d | 18±10 | 18±10 | 15±8 | <0.001 |
| APOL1 risk allele frequencies | ||||
| G1 | 0.22 | — | — | — |
| G2 | 0.13 | — | — | — |
| APOL1 genotype frequencies, n (%) | ||||
| WT/WT | 1270 (41.4) | — | — | — |
| WT/G1 | 859 (28.0) | — | — | — |
| WT/G2 | 534 (17.4) | — | — | — |
| G1/G2 | 201 (6.6) | — | — | — |
| G1/G1 | 153 (5.0) | — | — | — |
| G2/G2 | 50 (1.6) | — | — | — |
Aa±.5±e F Glomerular Filtration
a
Fasting blood glucose was available in 2877 participants overall (2504 participants carrying zero or one risk allele and 373 participants carrying two risk alleles).
b
Body mass index was available in 3064 participants (2661 participants with zero or one allele and 403 participants with two alleles).
c
HDL and total cholesterol were available in 3006 participants (2611 participants with zero or one allele and 395 participants with two alleles).
d
Global ancestry was available in 2740 participants (2373 participants with zero or one allele and 367 participants with two alleles).