Table 3.
HRs (95% CIs) for incident CKD and incident ESRD associated with two copies of APOL1 risk alleles (compared with zero or one risk allele) stratified by baseline diabetes and hypertension status
| Model | HR (95% CI) | P Value | HR (95% CI) | P Value |
|---|---|---|---|---|
| Incident CKD | ||||
| Stratified by diabetes (P for interaction=0.82) | No diabetes (n=2531) | Diabetes (n=536) | ||
| Model 1a | 1.54 (0.95 to 2.49) | 0.08 | 1.41 (0.76 to 2.60) | 0.27 |
| Model 2b | 1.57 (0.95 to 2.61) | 0.08 | 1.43 (0.72 to 2.81) | 0.30 |
| Stratified by hypertension (P for interaction=0.08) | No hypertension (n=1423) | Hypertension (n=1644) | ||
| Model 1a | 2.43 (1.24 to 4.78) | 0.01 | 1.13 (0.71 to 1.79) | 0.60 |
| Model 2b | 2.53 (1.25 to 5.14) | 0.01 | 1.12 (0.69 to 1.83) | 0.64 |
| Incident ESRD | ||||
| Stratified by diabetes (P for interaction=0.66) | No diabetes (n=2529) | Diabetes (n=536) | ||
| Model 1a | 2.00 (0.99 to 4.04) | 0.06 | 1.64 (0.92 to 2.92) | 0.09 |
| Model 2b | 2.04 (0.96 to 4.35) | 0.06 | 1.71 (0.91 to 3.21) | 0.09 |
| Stratified by hypertension (P for interaction=0.14) | No hypertension (n=1423) | Hypertension (n=1642) | ||
| Model 1a | 3.09 (1.42 to 6.73) | 0.004 | 1.45 (0.84 to 2.50) | 0.19 |
| Model 2b | 2.87 (1.20 to 6.87) | 0.02 | 1.53 (0.86 to 2.72) | 0.15 |
a
Model 1 adjusted for age, sex, and study center.
b
Model 2 adjusted for age, sex, study center, and percent European ancestry.