Table A3.

Hypoglycaemia risk in the pooled type 2 and type 1 diabetes mellitus population

	Estimated Rate Ratio* (95% Confidence Interval)
Population	Pooled T2DM and T1DM
Number of subjects
IDeg†	2899
I Glar†	1431
Overall confirmed hypoglycaemic episodes
Entire treatment period	0.91 [0.83;0.99]‡
Titration period	1.00 [0.90;1.10]
Maintenance period	0.84 [0.75;0.93]‡
Nocturnal confirmed hypoglycaemic episodes
Entire treatment period	0.74 [0.65;0.85]‡
Titration period	0.86 [0.74;1.00]‡
Maintenance period	0.68 [0.58;0.80]‡
Severe hypoglycaemic episodes
Entire treatment period	0.98 [0.66;1.45]

IDeg, insulin degludec; IGlar, insulin glargine; T2DM, type 2 diabetes mellitus; T1DM, type 1 diabetes mellitus.

^*Estimated rate ratio: IDeg/IGlar.

^†IDeg and IGlar were both injected once daily.

^‡Significantly lower risk with insulin degludec based on 95% confidence interval.