Fig. 3.

Divergence of G2019S PD brains in levels of highly aggregated urea-soluble α-synuclein species. The urea-soluble fractions of basal ganglia (A) and limbic cortex (B) of G2019S, iPD and control brains were analysed for the presence of α-synuclein. Aggregated α-synuclein is observed in the basal ganglia and the limbic cortex of the iPD samples following pathology severity. Very little aggregated synuclein is detected in the urea-soluble samples of the G2019S cases compared to the iPD cases. A dot-blot of urea-fractions of the basal ganglia (C) reveals much lower levels of α-synuclein in the G2019S cases compared to that of the iPD samples, whilst no α-synuclein is detected in controls. [ANOVA with Bonferroni's correction: *p < 0.01].