Table 2.

Immunohistochemistry scores for phosphorylated α-synuclein depositions in the various regions studied. Severity of pS129 α-synuclein positive pathology from different regions of G2019S and idiopathic PD cases was scored by two researchers independently on a three point scoring system where “+”, “++”, “+++” indicate mild, moderate and severe pathologies respectively. N/A indicates section not available for staining. DMN = dorsal motor nucleus of the vagus.

Case	DMN	Midbrain	Striatum	Entorhinal cortex	Cingulate gyrus	Frontal cortex
G2019S 1	+++	+++	+++	+++	N/A	+
G2029S 2	+++	+++	++	N/A	N/A	+
G2019S 3	+++	++	+++	++	+	+
G2019S 4	N/A	++	++	+++	+	+
iPD 1	++	+++	++	+++	+	+
iPD 2	++	+++	++	+++	+	+
iPD 3	+++	+++	++	++	+	+
iPD 4	++	++	+++	++	+	+