Figure 2.

Box Plot Representation of the Log Residual Values Obtained by ¹³C-FSA

Combinations of up to three intracellular carbon substrates were tested from 14 potential sources (alanine [ALA], acetate [ACE], glucose, glycerol, asparagine/aspartate [ASP], glutamate/glutamine [GLU], histidine [HIS], isoleucine [ISO], leucine [LEU], lysine [LYS], serine [SER], threonine [THR], tyrosine [TYR], and valine [VAL]). One and two carbon sources are represented by single bars, whereas three carbon sources are represented by two bars (with and without ALA). The inset histogram represents the logged residual values for combinations of three substrates, including ALA and ACE, showing that the optimal combination of substrates is ACE, ALA, and SER. The box plots depict the interquartile range (IQR) between the upper (Q3) and lower (Q1) quartiles (blue lines) and the median (red line). The length of the box represents the interquartile range (IQR). Whisker caps extend from the ends of the box within one IQR in each direction. Values more than one IQR from the upper whisker represent outliers, which are unlikely carbon sources (red cross), whereas values of less than one IQR from the lower whisker represent potential carbon substrates (green diamond) and are labeled with the name of the carbon source(s).