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. Author manuscript; available in PMC: 2013 Aug 27.
Published in final edited form as: Int J Cancer. 2008 Apr 15;122(8):1803–1809. doi: 10.1002/ijc.23308

FIGURE 2.

FIGURE 2

Colon architecture in PACAP KO mice given normal drinking water (a) or 3 cycles of DSS (b and c). Note in panel b the extensive inflammatory infiltration in the mucosa and submucosa, and the complete loss of recognizable crypt structures and surface epithelium, and the presence of a lymphoid aggregate in the mucosa. Panel c is a high power magnification of the boxed area in panel b showing prominent infiltration of macrophages and lymphocytes. Neutrophils are also present. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]