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The chemical structure and biological evaluation of tri- and tetra-substituted derivatives of the pilicide scaffold
| |||||
|---|---|---|---|---|---|
| ID | R8 (C-8) | R7 (C-7) | R6 (C-6) | R2 (C-2) | EC50 (μM)a |
| 58 |
|
|
|
|
5 |
| 59 |
|
|
|
|
5 |
| 60 |
|
|
–H |
|
86 |
| 61 |
|
|
–H |
|
20 |
| 33 |
|
|
–H | –H | 10 |
| 22 |
|
|
–H | –H | 21 |
Estimated from 16 to 72 data points per concentration.
