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Year of approval by FDA of AAPDs for bipolar disorder.
| Acute mania/mixed episodes | Bipolar disorder maintenance Tx | Acute bipolar depression | |
|---|---|---|---|
| Olanzapine | 2000 | 2004 | 2003a |
| Quetiapine | 2004 | 2004b | 2008 |
| Risperidone | 2003 | 2009c | |
| Aripiprazole | 2004 | 2004 | |
| Asenapine | 2007 | ||
| Lurasidone | 2013d |
Olanzapine/flluoxetine combination.
In combination with valproate/lithium.
Depot formulation.
Both for monotherapy and in combination with valproate/lithium.
