Table 1.
Wieberdink grades19
| Grade I | No visible effect |
| Grade II | Slight erythema and/or edema |
| Grade III | Considerable erythema and/or edema |
| Grade IV | Extensive epidermolysis and/or obvious damage to deep tissues with a threatened or actual compartment syndrome |
| Grade V | Severe tissue damage necessitating amputation |
Notes: Reprinted from Eur J Cancer Clin Oncol,18, Wieberdink J, Benckhuysen C, Braat RP, et al, Dosimetry in isolation perfusion of the limbs by assessment of perfused tissue volume and grading of toxic tissue reactions, 905–910. Copyright © 1982, with permission from Elsevier.19