. Author manuscript; available in PMC: 2013 Aug 27.

Published in final edited form as: Nat Rev Cardiol. 2012 Dec 11;10(2):98–110. doi: 10.1038/nrcardio.2012.178

Table 1.

Cardiac resynchronization therapy in patients with mild HF

Study	Number of patients	NYHA class	LVEF (%)	QRS duration (ms)	Primary end point	Effect on primary end point
REVERSE⁴⁵	610	I–II	≤40%	≥120	HF clinical composite score	Not significant
MADIT-CRT⁴⁶	1,820	I–II	≤30%	≥130	Death from any cause or a nonfatal HF event	Significant
RAFT⁵⁰	1,798	II–III	≤30%	≥130	Death from any cause or hospitalization for HF	Significant

Abbreviations: HF, heart failure; LVEF, left ventricular ejection fraction.