Antibacterial efficacies and resistance profiles for S. pneumoniae containing the parC or parE mutation or both mutations after exposure to simulated human epithelial lining fluid levofloxacin concentrations. ▪, MIC for isolate 1312; ○, isolate 1312; □, MIC for isolate 1386; ▵, isolate 1386; shaded square, MIC for isolate 1610; ⋄, isolate 1610.