TABLE 2.
Simulated dosing regimens, target human epithelial lining fluid drug concentrations, and corresponding pharmacokinetic profiles observed in in vitro simulations
| Antibiotic (regimen), parameter, and isolate | Peak concn (μg/ml)a | Trough concn (μg/ml)b | AUC0-24 (μg · h/ml)c |
|---|---|---|---|
| Levofloxacin (500 mg every 24 h) | |||
| Target valuec (mean [±SD]) | 15.23 (4.53) | 2.94 (1.74) | 180 |
| Actual value (mean [±SD])d | |||
| 53 | 13.79 (2.11) | 4.38 (0.50) | 268 (34) |
| 1911 | 17.52 (1.58) | 3.33 (0.50) | 203 (22) |
| 93 | 15.82 (0.20) | 3.52 (0.20) | 193 (4) |
| 1312 | 16.75 (1.52) | 3.83 (0.15) | 200 (15) |
| 1386 | 18.19 (0.21) | 3.20 (0.58) | 202 (18) |
| 1610 | 17.88 (0.66) | 2.80 (0.39) | 194 (5) |
| Moxifloxacin (400 mg every 24 h) | |||
| Target valuec (mean [±SD]) | 11.66 (11.9) | 5.71 (6.3) | 208 |
| Actual value (mean [±SD])d | |||
| 53 | 11.47 (0.17) | 5.62 (0.23) | 201 (1) |
| 1911 | 10.97 (0.29) | 5.76 (0.55) | 198 (9) |
| 93 | 12.51 (0.16) | 6.21 (0.46) | 222 (4) |
| 1312 | 11.73 (0.52) | 5.92 (0.35) | 199 (17) |
a
Values were obtained at 4 h after dose administration.
b
Values were obtained at 24 h after dose administration.
c
Adapted from reference 4.
d
Values are presented as the means for the three treatment models.