TABLE 2.
emm types and MLST of 54 erythromycin-resistant S. pyogenes strains isolated from outpatients in Germany from 1999 to 2000a
| Genotype (n) | MSR strain no. | Town of origin | Source | Infection | MIC (μg/ml)
|
Macrolide resistance
|
emm | MLST allele
|
ST | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ERY | TEL | CLI | GT | PT | gki | gtr | murL | mutS | recP | xpt | yqiL | |||||||
| mef(A) (30) | 18 | Dillingen/Saar | Throat swab | Tonsillopharyngitis | 1 | 0.03 | 0.25 | mef(A) | M | 1 | 4 | 3 | 4 | 4 | 4 | 2 | 4 | 28 |
| 54 | Plön | Throat swab | Tonsillopharyngitis | 16 | 0.25 | 0.25 | mef(A) | M | 1 | 4 | 3 | 4 | 4 | 4 | 2 | 4 | 28 | |
| 750 | Neukirchen | Swab | Wound infection | 16 | 0.25 | 0.03 | mef(A) | M | 1 | 4 | 31 | 2 | 4 | 4 | 2 | 16 | 28−V1 | |
| 331 | Weiden | Throat swab | Tonsillopharyngitis | 8 | 0.5 | 0.03 | mef(A) | M | 1 | 4 | 3 | 4 | 4 | 4 | 2V | 4 | 28−V2 | |
| 332 | Weiden | Throat swab | Tonsillopharyngitis | 16 | 0.5 | 0.06 | mef(A) | M | 1 | 4 | 3 | 4 | 4 | 4 | 2V | 4 | 28−V2 | |
| 699 | Weiden | Throat swab | Tonsillopharyngitis | 16 | 1 | 0.03 | mef(A) | M | 1 | 4 | 3 | 4 | 4 | 4 | 2V | 4 | 28−V2 | |
| 361 | Dillingen/Saar | Throat swab | Tonsillopharyngitis | 8 | 0.5 | 0.03 | mef(A) | M | 2 | 11 | 9 | 1 | 9 | 2 | 3 | 4 | 55 | |
| 576 | Dillingen/Saar | Throat swab | Tonsillopharyngitis | 2 | 0.03 | 0.03 | mef(A) | M | 3 | 2 | 6 | 8 | 5 | 2 | 3 | 2 | 15 | |
| 403 | Dillingen/Saar | Swab | Wound infection | 4 | 0.125 | 0.03 | mef(A) | M | 4 | 5 | 11 | 8 | 5 | 15 | 2 | 1 | 39 | |
| 42 | Trier | Throat swab | Tonsillopharyngitis | 8 | 0.25 | 0.125 | mef(A) | M | 4 | 5 | 11 | 8 | 5 | 15 | 2 | 1 | 39 | |
| 60 | Plön | Throat swab | Tonsillopharyngitis | 8 | 0.25 | 0.25 | mef(A) | M | 4 | 5 | 11 | 8 | 5 | 15 | 2 | 1 | 39 | |
| 254 | Wülfrath | Throat swab | Tonsillopharyngitis | 8 | 0.125 | 0.03 | mef(A) | M | 4 | 5 | 11 | 8 | 5 | 15 | 2 | 1 | 39 | |
| 267 | Neukirchen | Throat swab | Tonsillopharyngitis | 8 | 0.25 | 0.03 | mef(A) | M | 4 | 5 | 11 | 8 | 5 | 15 | 2 | 1 | 39 | |
| 295 | Dillingen/Saar | Throat swab | Tonsillopharyngitis | 8 | 0.25 | 0.03 | mef(A) | M | 4 | 5 | 11 | 8 | 5 | 15 | 2 | 1 | 39 | |
| 582 | Dillingen/Saar | Ear | Wound infection | 8 | 0.25 | 0.03 | mef(A) | M | 4 | 5 | 11 | 8 | 5 | 15 | 2 | 1 | 39 | |
| 598 | Plön | Throat swab | Tonsillopharyngitis | 8 | 0.125 | 0.03 | mef(A) | M | 4 | 5 | 11 | 8 | 5 | 15 | 2 | 1 | 39 | |
| 51 | Plön | Throat swab | Tonsillopharyngitis | 16 | 0.25 | 0.125 | mef(A) | M | 4 | 5 | 11 | 8 | 5 | 15 | 2 | 1 | 39 | |
| 52 | Plön | Throat swab | Tonsillopharyngitis | 16 | 0.25 | 0.25 | mef(A) | M | 4 | 5 | 11 | 8 | 5 | 15 | 2 | 1 | 39 | |
| 61 | Plön | Throat swab | Tonsillopharyngitis | 16 | 0.5 | 0.06 | mef(A) | M | 4 | 4 | 11 | 8 | 5 | 15 | 2 | 1 | 39−V1 | |
| 583 | Dillingen/Saar | Throat swab | Tonsillopharyngitis | 8 | 0.25 | 0.03 | mef(A) | M | 4 | 5 | 11 | 8 | 3 | 15 | 2 | 1 | 39−V2 | |
| 5 | Leverkusen | Throat swab | Tonsillopharyngitis | 16 | 0.25 | 0.25 | mef(A) | M | 4 | 5 | 11V | 8 | 5 | 15 | 2 | 1 | 39−V3 | |
| 794 | Stuttgart | Throat swab | Tonsillopharyngitis | 16 | 0.25 | 0.03 | mef(A) | M | 5 | 33 | 30 | 7 | 5 | 5 | 26 | 3 | 99 | |
| 260 | Wülfrath | Swab | Wound infection | 4 | 0.25 | 0.03 | mef(A) | M | 12 | 5 | 2 | 2 | 6 | 6 | 2 | 2 | 36 | |
| 344 | Bonn | Swab | ND | 8 | 0.5 | 0.06 | mef(A) | M | 12 | 5 | 2 | 2 | 6 | 6 | 2 | 2 | 36 | |
| 695 | Dillingen/Saar | Throat swab | Tonsillopharyngitis | 16 | 0.25 | 0.03 | mef(A) | M | 12 | 5 | 2 | 2 | 6 | 6 | 2 | 2 | 36 | |
| 773 | Neukirchen | Throat swab | Tonsillopharyngitis | 16 | 0.5 | 0.03 | mef(A) | M | 12 | 5 | 2 | 2 | 6 | 6 | 2 | 2 | 36 | |
| 144 | Dillingen/Saar | Swab | Wound infection | 8 | 0.25 | 0.25 | mef(A) | M | 12 | 5 | 11 | 8 | 5 | 15 | 2 | 1 | 39 | |
| 591 | Bonn | Throat swab | Tonsillopharyngitis | 16 | 0.5 | 0.03 | mef(A) | M | 75 | 11 | 2 | 1 | 3 | 12 | 3 | 7 | 49 | |
| 567 | Weiden | Throat swab | Tonsillopharyngitis | 2 | 0.03 | 0.06 | mef(A) | M | 77 | 13 | 6 | 2 | 3 | 23 | 3 | 11 | 63 | |
| 206 | Bonn | Ear | ND | 16 | 0.5 | 0.03 | mef(A) | M | 77 | 5 | 2 | 2 | 6 | 6 | 2 | 2 | 36 | |
| erm(B) (7) | 564 | Weiden | Throat swab | Tonsillopharyngitis | 32 | 0.5 | 32 | erm(B) | c | 1 | 4 | 3 | 4 | 4 | 4 | 2V | 4 | 28−V2 |
| 63 | Hamburg | Throat swab | Tonsillopharyngitis | 32 | 32 | 32 | erm(B) | c | 12 | 5 | 2 | 2 | 6 | 6 | 2 | 2 | 36 | |
| 235 | Bad Hersfeld | Throat swab | Tonsillopharyngitis | 32 | 1 | 32 | erm(B) | c | 12 | 5 | 2 | 2 | 6 | 6 | 2 | 2 | 36 | |
| 610 | Stuttgart | Swab | Wound infection | 32 | 4 | 32 | erm(B) | c | 22 | 9 | 8 | 1 | 1 | 1 | 3 | 4 | 46 | |
| 76 | Hamburg | Throat swab | Scarlatina | 8 | 0.03 | 0.25 | erm(B) | i | 77 | 13 | 6 | 2 | 3 | 23 | 3 | 11 | 63 | |
| 44 | Trier | Throat swab | Tonsillopharyngitis | 32 | 0.03 | 0.25 | erm(B) | i | 77 | 13 | 6 | 2 | 3 | 23 | 3 | 11 | 63 | |
| 333 | Weiden | Throat swab | Tonsillopharyngitis | 32 | 0.06 | 0.25 | erm(B) | i | 77 | 16 | 2 | 8 | 3 | 1 | 13 | 3 | 101 | |
| erm(A) (17) | 227 | Osnabrück | Throat swab | Tonsillopharyngitis | 8 | 0.03 | 0.125 | erm(A) | i | 12 | 3 | 6 | 2 | 3 | 23 | 3 | 11 | New |
| 108 | Plön | Throat swab | Tonsillopharyngitis | 2 | 0.03 | 0.25 | erm(A) | i | 28 | 11 | 6 | 14 | 5 | 9 | 17 | 19 | 52 | |
| 247 | Trier | Throat swab | Tonsillopharyngitis | 2 | 0.03 | 0.03 | erm(A) | i | 28 | 11 | 6 | 14 | 5 | 9 | 17 | 19 | 52 | |
| 380 | Stuttgart | Swab | Wound infection | 2 | 0.03 | 0.03 | erm(A) | i | 44/61 | 4 | 2 | 3 | 11 | 17 | 3 | 1V | New | |
| 600 | Wülfrath | Swab | Erysipelas | 4 | 0.03 | 0.06 | erm(A) | i | 44/61 | 4 | 2 | 3 | 1 | 17 | 3 | 1V | New | |
| 393 | Leverkusen | Throat swab | Tonsillopharyngitis | 4 | 0.03 | 0.06 | erm(A) | i | 58 | 3 | 2 | 3 | 3 | 1 | 3 | 3 | 19−V1 | |
| 698 | Neukirchen | Swab | Wound infection | 2 | 0.03 | 0.06 | erm(A) | i | 77 | 13 | 6 | 2 | 3 | 23 | 3 | 11 | 63 | |
| 269 | Augsburg | Throat swab | Tonsillopharyngitis | 4 | 0.03 | 0.125 | erm(A) | i | 77 | 13 | 6 | 2 | 3 | 23 | 3 | 11 | 63 | |
| 50 | Plön | Throat swab | Tonsillopharyngitis | 2 | 0.03 | 0.03 | erm(A) | i | 77 | 13 | 6 | 2 | 3 | 23 | 3 | 11 | 63 | |
| 92 | Bad Hersfeld | Throat swab | Tonsillopharyngitis | 2 | 0.03 | 0.25 | erm(A) | i | 77 | 13 | 6 | 2 | 3 | 23 | 3 | 11 | 63 | |
| 77 | Hamburg | Throat swab | Scarlatina | 8 | 0.03 | 0.125 | erm(A) | i | 77 | 13 | 6 | 2 | 3 | 23 | 3 | 11 | 63 | |
| 113 | Plön | Throat swab | Tonsillopharyngitis | 8 | 0.03 | 0.25 | erm(A) | i | 77 | 13 | 6 | 2 | 3 | 23 | 3 | 11 | 63 | |
| 395 | Leverkusen | Throat swab | Tonsillopharyngitis | 8 | 0.03 | 0.125 | erm(A) | i | 77 | 13 | 6 | 2 | 3 | 23 | 3 | 11 | 63 | |
| 21 | Weiden | Swab | Wound infection | 32 | 0.03 | 0.125 | erm(A) | i | 77 | 13 | 6 | 2 | 3 | 23 | 3 | 11 | 63 | |
| 640 | Stuttgart | Throat swab | Tonsillopharyngitis | 2 | 0.03 | 0.03 | erm(A) | i | 77 | 13 | 6 | 2 | 3 | 9 | 3 | 11 | 63−V1 | |
| 690 | Berlin | Ear | Wound infection | 2 | 0.03 | 0.03 | erm(A) | i | 77 | 9 | 6 | 2 | 5 | 23 | 3 | 11 | 63−V2 | |
| 696 | Dillingen/Saar | BS | ND | 4 | 0.03 | 0.06 | erm(A) | i | 77 | 5 | 6 | 2 | 6 | 23 | 3 | 11 | 63−V3 | |
a
Abbreviations: TEL, telithromycin; ERY, erythromycin; CLI, clindamycin; BS, bronchial secretion; PT, phenotype; GT, genotype; i, inducible MLSB phenotype; c, constitutive MLSB phenotype; V, variant; ND, no data.