TABLE 3.
MICs for AmpC inducibility mutant series of Enterobacteriaceae
| Straina | MIC (μg/ml)b
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| DOR | MEM | IMP | ERT | PTZ | AZT | CAZ | CPM | AMP | |
| C. freundii | |||||||||
| C2 | 0.06 | 0.03 | 0.5 | 0.015 | 2 | 0.25 | 0.5 | 0.06 | >64 |
| C2-CON | 0.06 | 0.03 | 0.25 | 0.125 | 32 | 16 | 32 | 1 | >64 |
| C2-DEF | 0.06 | 0.015 | 0.25 | <0.008 | 2 | 0.125 | 0.5 | 0.06 | 16 |
| C4 | 0.125 | 0.03 | 1 | 0.015 | 16 | 1 | 2 | 0.06 | >64 |
| C4-CON | 0.03 | 0.03 | 0.5 | 0.03 | 4 | 4 | 32 | 0.125 | >64 |
| C4-DEF | 0.06 | 0.03 | 0.5 | <0.008 | 1 | 0.125 | 1 | <0.03 | 32 |
| C10 | 0.03 | 0.015 | 0.5 | <0.008 | 4 | 0.06 | 0.25 | <0.03 | 32 |
| C10-CON | 0.03 | 0.03 | 0.5 | 0.03 | 8 | 4 | 32 | 0.06 | >64 |
| C10-DEF | 0.03 | 0.015 | 0.06 | <0.008 | 1 | 0.06 | 0.125 | <0.03 | 4 |
| C12 | 0.03 | 0.015 | 0.25 | <0.008 | 4 | 0.125 | 0.5 | <0.03 | 16 |
| C12-CON | 0.125 | 0.06 | 1 | 0.06 | 8 | 4 | 32 | 0.06 | >64 |
| C12-DEF | <0.008 | <0.008 | 0.06 | <0.008 | 1 | 0.06 | 0.25 | <0.03 | 4 |
| E. cloacae | |||||||||
| 84-CON | 0.06 | 0.06 | 0.25 | 0.5 | 32 | 64 | >64 | 2 | >64 |
| 84-DEF | 0.03 | 0.015 | 0.25 | <0.008 | 4 | 0.5 | 1 | 0.06 | 64 |
| 100-CON | 0.06 | 0.03 | 0.25 | 0.015 | 2 | 2 | 2 | 0.06 | >64 |
| 100-DEF | <0.008 | <0.008 | <0.03 | <0.008 | <0.125 | <0.03 | <0.03 | <0.03 | 0.5 |
| 684 | 0.06 | 0.03 | 0.5 | 0.03 | 4 | 0.125 | 0.5 | 0.125 | >64 |
| 684-CON | 0.06 | 0.06 | 0.25 | 0.25 | 32 | 32 | 64 | 1 | >64 |
| 684-DEF | 0.06 | 0.015 | 0.25 | <0.008 | 2 | 0.06 | 0.125 | <0.03 | 4 |
| S. marcescens | |||||||||
| S2 | 0.06 | 0.03 | 2 | 0.03 | 16 | 0.125 | 0.125 | 0.06 | >64 |
| S2-CON | 0.06 | 0.03 | 1 | 0.03 | >64 | 4 | 2 | 1 | >64 |
| S2-DEF | 0.06 | 0.03 | 2 | 0.015 | 16 | 0.125 | 0.25 | 0.06 | >64 |
| S7 | 0.06 | 0.03 | 0.25 | 0.03 | 16 | 0.125 | 0.125 | 0.125 | >64 |
| S7-CON | 0.06 | 0.03 | 1 | 0.03 | 32 | 8 | 2 | 1 | >64 |
| S7-DEF | 0.125 | 0.06 | 2 | 0.03 | 16 | 0.125 | 0.25 | 0.125 | >64 |
| M. morganii | |||||||||
| M1 | 0.5 | 0.125 | 4 | 0.03 | 0.25 | <0.03 | 0.06 | <0.03 | >64 |
| M1-CON | 0.5 | 0.125 | 2 | 0.03 | <0.125 | 0.5 | 4 | <0.03 | >64 |
| M1-DEF | 0.25 | 0.06 | 1 | <0.008 | 0.25 | <0.03 | 0.06 | <0.03 | 4 |
| M3-CON | 0.5 | 0.125 | 2 | 0.03 | 0.5 | 0.5 | 16 | <0.03 | >64 |
| M3-DEF | 0.25 | 0.06 | 2 | 0.015 | 0.25 | <0.03 | 0.06 | <0.03 | 2 |
| M6 | 0.06 | 0.03 | 1 | 0.015 | 0.25 | <0.03 | 0.06 | <0.03 | 64 |
| M6-CON | 0.5 | 0.125 | 2 | 0.03 | 0.25 | 0.05 | 8 | <0.03 | >64 |
| M6-DEF | 0.25 | 0.06 | 1 | 0.015 | 0.25 | <0.03 | 0.06 | <0.03 | 4 |
| P. vulgaris | |||||||||
| VA1 | 0.5 | 0.125 | 4 | 0.03 | 1 | 0.06 | 0.125 | 0.125 | >64 |
| VA1-CON | 0.25 | 0.06 | 2 | 0.015 | 0.5 | 0.06 | 0.125 | 0.125 | >64 |
| VA1-DEF | 0.125 | 0.03 | 0.5 | <0.008 | 0.5 | <0.03 | <0.03 | <0.03 | 32 |
| V2 | 0.25 | 0.06 | 2 | 0.015 | 1 | <0.03 | 0.06 | 0.125 | >64 |
| V2-CON | 0.125 | 0.03 | 1 | 0.015 | 1 | 0.06 | 0.125 | 0.25 | >64 |
| V2-DEF | 0.125 | 0.03 | 1 | 0.015 | 0.5 | <0.03 | <0.03 | 0.06 | 32 |
| V3 | 0.25 | 0.06 | 2 | 0.015 | 0.5 | <0.03 | <0.03 | 0.06 | >64 |
| V3-CON | 0.25 | 0.06 | 2 | 0.015 | 0.5 | 0.125 | 0.125 | 0.25 | >64 |
| V3-DEF | 0.25 | 0.06 | 1 | 0.015 | 0.5 | 0.06 | 0.06 | 0.06 | 32 |
a
CON, constitutively hyperproducing AmpC enzyme irrespective of induction; DEF, deficient: making only a trace amount of AmpC enzyme irrespective of induction.
b
Abbreviations for antibiotics are as defined in Table 2.