Table 1.
Preparation recipes and characteristics of LNE with different weight ratio of soybean oil to MCT
| Materials (mg)
|
Physicochemical properties
|
||||||
|---|---|---|---|---|---|---|---|
| Soybean oil | MCT | Lecithin | dn (nm) | Zeta potential (mV) | EE (%) | DL (%) | |
| A | 80 | 20 | 12 | 126.4 ± 8.7* | −22.4 ± 4.6 | 79.2 ± 2.1 | 4.0 ± 0.1 |
| B | 60 | 40 | 12 | 97.2 ± 7.6* | −27.4 ± 5.2 | 78.5 ± 3.3 | 4.0 ± 0.2 |
| C | 50 | 50 | 12 | 56.2 ± 7.6* | −26.3 ± 3.5 | 75.2 ± 1.4 | 3.8 ± 0.1 |
| D | 40 | 60 | 12 | 44.5 ± 9.3* | −25.6 ± 7.3 | 71.2 ± 2.9 | 3.6 ± 0.1 |
| E | 20 | 80 | 12 | 64.8 ± 8.7* | −27.8 ± 6.1 | 66.2 ± 3.8 | 3.3 ± 0.2 |
Notes: Data are expressed as the mean ± standard deviation (n = 3);
*
indicates significant difference (P < 0.05).
Abbreviations: LNE, lipid nanoemulsion; MCT, medium-chain triglyceride; dn, hydrodynamic diameter of LNE; EE (%), drug encapsulation efficiency; DL (%), drug loading content.