Suggested intervals of follow-up for patients with metastatic disease1
	Baseline prior to new therapy	Chemotherapy	Endocrine therapy	Restaging if concern for progression of disease
Symptom assessment	Yes	Prior to each cycle	Every 2–3 months	Yes
Physical examination	Yes	Prior to each cycle	Every 2–3 months	Yes
Performance status	Yes	Prior to each cycle	Every 2–3 months	Yes
Weight	Yes	Prior to each cycle	Every 2–3 months	Yes
LFTs, CBC	Yes	Prior to each cycle	Every 2–3 months	Yes
CT scan chest/abd/pelvis	Yes	Every 2–4 cycles	Every 2–6 months	Yes
Bone scan	Yes	Every 4 cycles	Every 4–6 months	Yes
PET/CT	Optional	Unknown	Unknown	Optional
Tumor markers	Optional	Optional	Optional	Optional
1 In patients who have long-term stable disease, the frequency of monitoring can be reduced.