Table 3.
Top SNPs from the DARE cohort (p<0.05) associated with the continuous QTc interval in 74 controls ordered according to their significance together with the results of the BRIGHT cohort (n=1480) and of the meta-analysis of the two cohorts. Significantly associated are shown in bold (p<5.2×10−4). P-values <0.01 are shown in italic.
| DARE |
BRIGHT |
Meta-analysis |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Position | Allele | Beta | SE | P-value | Beta | SE | P-value | Beta | SE | P-value |
| rs12734991 | 160461200 | C | 11.1 | 3.1 | 6.4×10−4 | 3.5 | 0.9 | 1.7×10−4 | 4.2 | 0.9 | 3.5×10−6 |
| rs4657166 | 160427963 | G | 11.5 | 3.6 | 0.0023 | 2.6 | 1.0 | 0.010 | 3.2 | 1.0 | 0.00091 |
| rs12733377 | 160519067 | G | 9.3 | 3.1 | 0.0037 | 3.3 | 0.9 | 4.0×10−4 | 3.8 | 0.9 | 2.0×10−5 |
| rs12729882 | 160508661 | A | 8.9 | 3.0 | 0.0049 | 3.1 | 0.9 | 8.6×10−4 | 3.6 | 0.9 | 5.2 ×10−5 |
| rs2661818 | 160531438 | G | 8.6 | 3.0 | 0.0051 | 4.0 | 0.9 | 1.7×10−5 | 4.4 | 0.9 | 6.1×10−7 |
| rs10399680 | 160480119 | C | 11.1 | 3.8 | 0.0052 | 3.7 | 1.1 | 7.9×10−4 | 4.2 | 1.0 | 5.7×10−5 |
| rs6664702 | 160471531 | C | 11.7 | 4.4 | 0.0099 | 3.6 | 1.1 | 0.0013 | 4.1 | 1.1 | 1.6×10−4 |
| rs1964052 | 160602048 | T | 11.6 | 4.4 | 0.011 | −1.1 | 1.4 | 0.44 | 0.1 | 1.3 | 0.95 |
| rs4298709 | 160503206 | G | 8.5 | 3.3 | 0.011 | 3.0 | 0.9 | 0.0015 | 3.4 | 0.9 | 1.6×10−4 |
| rs10918936 | 160469112 | A | 8.1 | 3.1 | 0.011 | 2.9 | 1.0 | 0.0025 | 3.3 | 0.9 | 2.5×10−4 |
| rs6427664 | 160481097 | A | 11.1 | 4.3 | 0.012 | 3.7 | 1.1 | 7.6×10−4 | 4.2 | 1.1 | 9.1×10−5 |
| rs905720 | 160600724 | T | 8.5 | 3.5 | 0.018 | −0.4 | 1.0 | 0.73 | 0.4 | 1.0 | 0.72 |
| rs4557949 | 160477578 | A | 8.0 | 3.3 | 0.019 | 3.8 | 0.9 | 4.9×10−5 | 4.1 | 0.9 | 4.8×10−6 |
| rs4145621 | 160485312 | C | 8.0 | 3.3 | 0.019 | 3.9 | 0.9 | 3.7×10−5 | 4.2 | 0.9 | 3.5×10−6 |
| rs10800397 | 160503714 | T | 11.5 | 4.8 | 0.019 | 4.2 | 1.1 | 3.0×10−5 | 4.6 | 1.1 | 4.3×10−5 |
| rs10800404 | 160521736 | T | 11.5 | 4.8 | 0.019 | 4.4 | 1.2 | 1.4×10−4 | 4.8 | 1.1 | 1.9×10−5 |
| rs12135795 | 160416389 | A | 7.6 | 3.2 | 0.019 | 2.3 | 0.9 | 0.016 | 2.7 | 0.9 | 0.0026 |
| rs10753765 | 160418397 | G | 7.6 | 3.2 | 0.019 | 2.3 | 0.9 | 0.016 | 2.7 | 0.9 | 0.0026 |
| rs3927640 | 160422437 | T | 7.6 | 3.2 | 0.019 | 2.3 | 0.9 | 0.015 | 2.7 | 0.9 | 0.0025 |
| rs4657161 | 160422913 | G | 7.6 | 3.2 | 0.019 | 2.3 | 0.9 | 0.015 | 2.7 | 0.9 | 0.0025 |
| rs12090585 | 160305400 | A | −8.9 | 3.9 | 0.024 | NA | NA | NA | NA | NA | NA |
| rs347271 | 160585953 | A | 19.6 | 8.7 | 0.027 | 2.4 | 2.5 | 0.34 | 3.7 | 2.4 | 0.12 |
| rs4328057 | 160458029 | G | 19.7 | 8.8 | 0.028 | −1.8 | 3.1 | 0.57 | 0.6 | 2.9 | 0.84 |
| rs10918951 | 160475138 | A | 11.6 | 5.4 | 0.036 | 0.2 | 2.1 | 0.91 | 1.7 | 2.0 | 0.38 |
| rs16859092 | 160491174 | C | 11.6 | 5.4 | 0.036 | −0.2 | 2.1 | 0.92 | 1.3 | 2.0 | 0.50 |
| rs12742393 | 160491210 | A | 6.9 | 3.3 | 0.039 | 3.2 | 0.9 | 7.5×10−4 | 3.5 | 0.9 | 1.3×10−4 |
| rs4656364 | 160545479 | C | 10.0 | 4.8 | 0.040 | 3.3 | 1.5 | 0.033 | 3.9 | 1.5 | 0.0076 |
| rs10753784 | 160515544 | G | 6.6 | 3.2 | 0.043 | 3.3 | 1.0 | 5.5×10−4 | 3.6 | 0.9 | 9.4×10−5 |
| rs10919035 | 160510636 | T | 14.1 | 6.9 | 0.043 | 5.1 | 1.4 | 3.3×10−4 | 5.5 | 1.4 | 8.1×10−5 |
NA: not available; SE: standard error