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IL-6-activated STAT3 signaling upregulates RORγt to promote Th17 cell differentiation through naïve T cells. High levels of TGF-β1 in ACS patients promote Treg cells differentiation but may inhibit Th17 cell differentiation. Imbalanced Th17 and Treg cell frequencies in ACS patients may originate from the reciprocal modulations by IL-6 and TGF-β1.
