Table 3. Candidate genes involved in L. vannamei immune response.

Category or gene ID	Homologous functiona	Species	FCb
Apoptosis pathway
RL-all_c360	Beclin	Pediculus humanus corporis	1.43
RL-all_c13	Catalase	Fenneropenaeus chinensis	−2.08
RL-all_rep_c11491	Oncoprotein nm23	Litopenaeus vannamei	2.71
RL-all_rep_c8488	Cathepsin B	Litopenaeus vannamei	2.02
RL-all_c667	Deoxyribonuclease I	Litopenaeus vannamei	−1.02
RL-all_c6511	Prohibitin	Litopenaeus vannamei	−2.02
RL-all_c58	Caspase	Fenneropenaeus chinensis	1.46
MAPK signaling pathway
RL-all_rep_c8373	Heat shock protein 70	Litopenaeus vannamei	1.15
RL-all_c1444	Max protein	Apis mellifera	2.24
RL-all_c5388	P38 mapk	Aedes aegypti	4.03
Toll-like receptor pathway
RL-all_c191	Polyubiquitin-C	Branchiostoma floridae	1.89
RL-all_c58	Caspase	Fenneropenaeus chinensis	1.46
Wnt signaling pathway
RL-all_c1445	Ring box protein	Bombyx mori	−1.15
RL-all_c8036	Transmembrane receptor	Ixodes scapularis	−1.56
RL-all_c458	Caprin-1	Harpegnathos saltator	−1.57
Antigen processing and presentation pathway
RL-all_rep_c11429	Cathepsin L	Penaeus monodon	1.02
RL-all_rep_c8488	Cathepsin B	Litopenaeus vannamei	2.01
RL-all_c7990	Autoantigen	Rhipicephalus appendiculatus	1.02
RL-all_rep_c12441	Legumain	Haemaphysalis longicornis	1.18
RL-all_rep_c12517	Gamma-interferon-inducible lysosomal thiol reductase	Penaeus monodon	−1.88

^aThe functions of homologous gene.

^bFC, fold changes (log2 ratio) in gene expression.