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. 2013 Aug 26;8(8):e70109. doi: 10.1371/journal.pone.0070109

Figure 2. Requirements of β-adrenergic signaling and PGC-1α in Bmal1 expression.

Figure 2

A. qPCR analyses of BAT gene expression in saline-injected mice housed at room temperature (24°C, n = 4) and mice treated with saline (filled, n = 4) or propranolol (grey, n = 4) after 3 hrs of cold exposure. Data represent mean ± SEM, saline vs. propranolol at 4°C, *p<0.05. B. Bmal1 mRNA expression in WT (filled) and PGC-1α null (open) mouse brown fat. Mice were housed at ambient temperature (n = 4 per WT or KO group) or subjected to cold exposure for 3.5 hrs (n = 6 per WT or KO group). Data represent mean ± SEM, WT vs. KO, *p<0.05. **p<0.01.