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. 2013 Aug 26;8(8):e74425. doi: 10.1371/journal.pone.0074425

Figure 3. RedRif’s effect on P-glycoprotein activity – rhodamine 123 efflux ratio.

Figure 3

P-gp activity is proportional to the ratio between Rho123 intracellular fluorescence from inhibited (+CyA) and non-inhibited (-CyA) cells. A significant increase in P-gp activity was found in RedRif-treated cells after 24 (P-gp activation effect) and 72h (P-gp induction effect) of exposure. Rif did not significantly change P-gp activity. Results refer to mean ± SD of at least 3 independent experiments performed in triplicate. Differences between treated and untreated cells were estimated using two-way ANOVA followed by Bonferroni’s multiple comparison post hoc test. ***p<0.001 vs. control.