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. 2013 Aug 26;8(8):e74253. doi: 10.1371/journal.pone.0074253

Figure 1. Effect of LBH589 on cell growth and effect of RT or combination treatment (LBH589 and RT) on colony forming in CaP cell lines and normal epithelial prostate cell line.

Figure 1

(A) Cells were treated with a range of concentrations of LBH589 for 24, 48 and 72 h; (B) Cells were treated with RT or combination with RT and LBH589 for analysis of colony-forming efficiency. Survival fractions were significantly reduced in PC-3 and LNCaP CaP cells (p<0.01), but not in normal REWP-1 cells (p>0.05); (C) Typical images are shown for colony growth in RT and combination treatment (LBH589 and RT) in CaP and normal prostate cells. All results were from three independent experiments (N=3). Points, mean; bars, SD.