TABLE 2.
Cumulative radioactivity excretion in urine and feces of caspofungin in rats, rabbits, and monkeys after a single intravenous dosea
| Species | Dose (mg/kg) | Collection period (days) | % of dose excreted in feces | % of dose excreted in urine | Total % of dose excreted |
|---|---|---|---|---|---|
| Rat | 2 | 12 | 29.4 ± 2.5 | 42.1 ± 1.3 | 71.5 ± 1.8 |
| Rabbit | 5 | 28 | 50.8 ± 3.0 | 36.0 ± 4.4 | 86.8 ± 2.9 |
| Monkey | 5 | 28 | 36.2 ± 0.7 | 45.4 ± 0.3 | 81.6 ± 1.1 |
Data are presented as means ± standard deviation for three rats and monkeys and four rabbits.