Table 2. Case-control association analysis for SNPs within AR/EDA2R, HDAC9 and 20p11 in 445 Han Chinese patients with AGA and 546 controls.
| SNP | Samplea | locus | Positionb | European | Chinese Han | |||||||||||||
| Cases | Controls | Ac/B Allele | MAFd (Case/Control) | Risk allele | Allelic P | Risk Allelic OR(95%CI) | Ref | Ac/B Allele | MAFd (Case/Control) | Genotypese | Risk Allele | Allelic Pf | Risk Allelic OR(95%CI) | Power(%) | ||||
| Cases | Controls | |||||||||||||||||
| rs6137444 | 445 | 546 | 20p11 | 21733639 | C/T | 0.269/0.391 | T | 2.20×10−10 | 1.74(1.37–2.21) | [13] | C/T | 0.272/0.401 | 34/174/237 | 96/246/204 | T | 1.68×10−9 | 1.79 (1.49–2.17) | 98 |
| rs2180439 | 444 | 540 | 20p11 | 21801100 | C/T | 0.293/0.452 | T | 2.67×10−15 | 1.82(1.45–2.30) | C/T | 0.271/0.417 | 29/183/232 | 108/234/198 | T | 1.84×10−11 | 1.92(1.59–2.33) | 99 | |
| rs1998076 | 445 | 540 | 20p11 | 21828045 | A/G | 0.292/0.448 | G | 7.73×10−15 | 1.9(1.50–2.41) | A/G | 0.270/0.411 | 29/182/234 | 102/240/198 | G | 5.28×10−11 | 1.89(1.56–2.27) | 99 | |
| rs201571 | 443 | 546 | 20p11 | 21961514 | C/T | 0.298/0.44 | T | 1.21×10−12 | 1.72(1.36–2.17) | T/C | 0.428/0.324 | 77/225/141 | 72/210/264 | T | 2.10×10−6 | 1.56(1.30–1.87) | 97 | |
| rs6113491 | 445 | 546 | 20p11 | 22005415 | A/C | 0.641/0.488 | A | 1.13×10−13 | 1.66(1.33–2.08) | A/C | 0.425/0.313 | 81/216/148 | 66/210/270 | A | 2. 82×10−7 | 1.62(1.35–1.95) | 98 | |
| rs3852255 | 445 | 546 | HDAC9 | 18832972 | T/C | 0.045/0.030 | T | 1.45×10−1 | 1.54(0.87–2.72) | [11] | T/C | 0.136/0.143 | 10/101/334 | 6/144/396 | C | 6.59×10−1 | 1.06(0.82∼1.37) | 70 |
| rs13230142 | 445 | 534 | HDAC9 | 18848034 | A/G | 0.030/0.013 | A | 3.10×10−2 | 2.37(1.05–5.37) | A/G | 0.117/0.118 | 8/88/349 | 6/114/414 | G | 9.39×10−1 | 1.01(0.77∼1.33) | 90 | |
| rs12056282 | 443 | 540 | HDAC9 | 18848728 | C/T | 0.043/0.022 | C | 2.90×10−2 | 1.98(1.05–3.75) | C/T | 0.135/0.144 | 11/98/334 | 6/144/390 | T | 5.67×10−1 | 1.08(0.83∼1.39) | 95 | |
| rs756853 | 442 | 534 | HDAC9 | 18856525 | G/A | 0.496/0.380 | G | 4.65×10−6 | 1.61(1.30–1.98) | A/G | 0.397/0.410 | 68/215/159 | 90/258/186 | G | 5.59×10−1 | 1.05(0.88∼1.27) | 92 | |
| rs2249817 | 445 | 540 | HDAC9 | 18862536 | G/A | 0.475/0.411 | G | 8.90×10−6 | 1.59(1.29–1.95) | A/G | 0.300/0.267 | 39/189/217 | 42/204/294 | A | 1.02×10−1 | 1.18(0.97∼1.44) | 82 | |
| rs10247184 | 445 | 546 | HDAC9 | 18879472 | T/C | 0.002/0 | T | 3.34×10−1 | – | T/C | 0.123/0.137 | 9/91/345 | 18/114/414 | T | 3.28×10−1 | 1.14(0.88∼1.49) | 90 | |
| rs10252945 | 441 | 528 | HDAC9 | 18891375 | A/C | 0.286/0.256 | A | 1.97×10−1 | 1.17(0.92–1.47) | A/C | 0.231/0.222 | 19/166/256 | 36/162/330 | A | 6.11×10−1 | 1.06(0.85∼1.31) | 52 | |
| rs17350355 | 444 | 546 | HDAC9 | 18895028 | A/G | 0.441/0.354 | A | 5.81×10−4 | 1.44(1.17–1.78) | A/G | 0.389/0.412 | 68/209/167 | 102/246/198 | G | 2.87×10−1 | 1.10(0.92∼1.32) | 36 | |
| rs1385699 | 445 | 546 | AR/EDA2R | 65741711 | C/T | 0.113/0.292 | T | 1.60×10−5 | 3.23(1.86–5.59) | [9] | T/T | 1.000/1.000 | 445 | 546 | – | NA | NA | NA |
| rs5919393 | 445 | 546 | AR/EDA2R | 66742082 | C/T | 0.046/0.218 | T | 6.00×10−7 | 5.82(2.73–12.41) | T/T | 1.000/1.000 | 445 | 546 | – | NA | NA | NA | |
| rs2497911 | 445 | 546 | AR/EDA2R | 66544165 | A/C | 0.038/0.283 | C | 2.30×10−4 | – | [10] | C/C | 1.000/1.000 | 445 | 546 | – | NA | NA | NA |
Note:
a, Total samples (445 cases and 546 controls), some samples failed to genotype in the experiment;.
b, In bp. NCBI build 36.3;.
c, Minor allele;.
d, MAF = Minor allele frequency;.
e, Numbers shown correspond to the following genotypes: AA/AB/BB (A = minor allele; B = major allele).
f, the threshold for statistical significance was P≤3.13×10−3.