Table 1. Plasma levels of cytokines, chemokines and growth factors (in pg/ml) at baseline and after 24 h of reperfusion.
Marker† | Baseline | NaCl | C1 INH |
EPO | 278.9±183.2 | 729.0±427.7 | 346.9±353.1 |
CXCL1 | 93.0±14.5 | 127.4±77.0 | 78.3±68.8 |
IFN-γ | 57.6±34.9 | 120.3±100.2 | 19.1±11.4* |
IL-1α | 9.0±4.9** | 83.1±44.9 | 16.9±10.3* |
IL-4 | 22.6±11.4 | 57.5±39.3 | 8.3±4.2 |
IL-5 | 96.5±11.2 | 172.7±73.6 | 108.3±23.7 |
IL-7 | 69.1±22.9** | 240.9±98.3 | 67.2±42.0** |
IL-10 | 306.6±51.3 | 776.3±508.0 | 279.1±94.2 |
IL-17A | 7.0±1.5** | 27.1±14.0 | 8.3±3.4** |
IL-18 | 1103.0±720.6** | 4155.0±1390.0 | 1115.0± 80.4** |
MCP-1 | 425.0±58.0* | 1693.0±982.4 | 1905.0±638.3 |
MIP-1α | 1097.0±968.0* | 4629.0±3045.0 | 1203.0±762.0* |
MIP-3α | 10.0±8.6** | 48.0 ± 20.2 | 12.0±9.5** |
RANTES | 164.0±89.1 | 310.2±309.7 | 389.0±442.7 |
TNF-α | 19.1±6.1 | 40.4±24.9 | 9.1±7.5* |
VEGF | 12.0±4.9 | 16.0±6.0 | 11.4±2.0 |
M-CSF | 293.6±50.8 | 381.2±117.1 | 459.1±79.2 |
EPO indicates Erythropoietin; CXCL1, Chemokine (C-X-C motif) Ligand 1; IFN-gamma, Interferon-gamma; IL, Interleukin; MCP-1, Monocyte chemotactic protein-1; MIP, Macrophage inflammatory protein; RANTES, Regulated and normal T cell expressed and secreted; TNF-α, Tumor necrosis factor-α; VEGF, Vascular endothelial growth factor; M-CSF, Macrophage colony-stimulating factor. Values are mean ± SD. P<0.05*; P<0.01** by ANOVA with Dunnett's post test vs. NaCl. Multiplex analysis of the shown markers was performed using a standard rat 24-plex panel from Bio-Rad. †IL-1β, IL-2, IL-6, IL12p70, IL-13, G-CSF, GM-CSF were below detection level and are not listed.