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. 2013 Aug 26;8(8):e72054. doi: 10.1371/journal.pone.0072054

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© 2013 Gach et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Amino acid alignment of the 1F7 (A) heavy chain and (B) light chain variable regions along with several other CD4bs antibodies. The 1F7 germline (gl) is shown in blue and residues that differ between 1F7 and its germline sequence are underlined. (A) Antibody F105 and 1F7 share the same variable heavy chain germline family IGHV4-59*01. However, the 1F7 heavy chain sequence is less conserved than the one of F105 (73.5% versus 91.8%). (B) The variable light chain of 1F7 derives from a different germline gene (IGKV1D-33*01) than the other CD4bs antibody light chain fragments.