Table 1.

Demographic and phenotypic Characteristics.

Pedigree number	Age at onset	Age at exam	Burke Fahn Marsden	UPDRS motor	Triggers	Presentation
I.1 [Parent]	59	64	36	27	Heat	Leg cramping 6 months prior to sudden onset dystonia with left foot incoordination, progressing over years to bilateral limb involvement, facial grimacing
II.1 [Child]	N/A	44	0	0	N/A	Asymptomatic
II.2 [Child]	18	38	58	34	Alcohol stress	Intermittent limb cramping over one year prior to sudden onset [overnight] dysarthria and asymmetric limb dystonia [R > L] and dysphagia
II.3 [Child]	18	39	41	18	Alcohol heat physical activity	Sudden onset [overnight] of dysarthria, progressing to asymmetric limb dystonia [R > L] and dysphagia over three weeks
II.4 [Child]	19	36	70.5	42	Heat stress	Sudden onset [overnight] asymmetric limb dystonia [L > R] followed by dysarthria, drooling, and generalized dystonia over several hours.