Table 2.
Prevalence of comorbidity, case-fatality rates and rate ratios for in-hospital death among adult hospitalizations with a diagnosis of VTE, NIS, 2009
| AHRQ comorbidity indexa | Unweighted n=153,124b |
Estimated N |
Prevalence of comorbidity | Association with in-hospital death | ||||
|---|---|---|---|---|---|---|---|---|
| % | 95% CIc | Case-fatality rate | 95% CI | Adjusted RRd | 95% CI | |||
| Acquired immune deficiency syndrome | 549 | 2,756 | 0.4 | 0.3-0.4 | 3.7 | 2.3-5.9 | -e | - |
| Alcohol abuse | 4,868 | 24,442 | 3.2 | 3.0-3.3 | 4.7 | 4.2-5.3 | 0.84 | 0.74-0.95 |
| Anemia (deficiency) | 38,261 | 192,405 | 24.9 | 23.9-25.8 | 5.9 | 5.6-6.3 | 0.72 | 0.68-0.76 |
| Arthritis (rheumatoid)/collagen vascular diseases | 5,209 | 26,254 | 3.4 | 3.3-3.5 | 4.9 | 4.4-5.6 | - | - |
| Chronic blood loss anemia | 2,904 | 14,636 | 1.9 | 1.8-2.0 | 5.6 | 4.8-6.6 | 0.66 | 0.57-0.77 |
| Congestive heart failuref | 19,627 | 99,176 | 12.8 | 12.4-13.3 | 10.8 | 10.3-11.4 | 1.43 | 1.36-1.50 |
| Chronic pulmonary disease | 32,301 | 163,376 | 21.1 | 20.5-21.7 | 6.8 | 6.4-7.2 | 1.07 | 1.02-1.12 |
| Coagulopathy | 12,685 | 63,524 | 8.2 | 7.8-8.6 | 13.6 | 12.8-14.4 | 1.84 | 1.74-1.94 |
| Depression | 15,878 | 80,027 | 10.3 | 10.0-10.7 | 3.6 | 3.3-4.0 | 0.72 | 0.67-0.79 |
| Diabetes, uncomplicated | 29,750 | 150,104 | 19.4 | 19.0-19.9 | 5.6 | 5.3-6.0 | - | - |
| Diabetes with chronic complications | 6,936 | 34,879 | 4.5 | 4.3-4.8 | 5.5 | 4.9-6.1 | 0.83 | 0.75-0.92 |
| Drug abuse | 3,806 | 19,116 | 2.5 | 2.3-2.7 | 3.3 | 2.8-4.0 | 0.80 | 0.67-0.95 |
| Hypertension (uncomplicated and complicated) | 82,484 | 416,519 | 53.9 | 53.0-54.7 | 5.0 | 4.7-5.2 | 0.70 | 0.66-0.73 |
| Hypothyroidism | 16,938 | 85,473 | 11.1 | 10.7-11.4 | 5.0 | 4.6-5.4 | 0.88 | 0.82-0.94 |
| Liver disease | 3,722 | 18,665 | 2.4 | 2.3-2.6 | 7.9 | 7.0-8.9 | 1.17 | 1.04-1.32 |
| Lymphoma | 2,512 | 12,719 | 1.6 | 1.5-1.8 | 9.4 | 8.3-10.7 | 1.43 | 1.27-1.62 |
| Fluid and electrolyte disorders | 43,505 | 218,526 | 28.3 | 27.4-29.1 | 10.8 | 10.4-11.2 | 1.90 | 1.82-1.98 |
| Metastatic cancer | 10,949 | 55,362 | 7.2 | 6.9-7.5 | 11.4 | 10.7-12.1 | 1.89 | 1.77-2.01 |
| Other neurological disorders | 14,270 | 72,079 | 9.3 | 9.1-9.6 | 6.2 | 5.8-6.7 | - | - |
| Obesity | 18,744 | 94,178 | 12.2 | 11.7-12.7 | 3.8 | 3.5-4.1 | 0.86 | 0.79-0.93 |
| Paralysis | 6,356 | 31,978 | 4.1 | 3.9-4.4 | 6.9 | 6.2-7.6 | 1.10 | 1.00-1.21 |
| Peripheral vascular disorders | 9,322 | 46,873 | 6.1 | 5.8-6.3 | 8.3 | 7.7-8.9 | 1.21 | 1.13-1.30 |
| Psychoses | 6,390 | 32,150 | 4.2 | 4.0-4.4 | 4.1 | 3.6-4.7 | 0.79 | 0.70-0.90 |
| Pulmonary circulation disorders | 30,267 | 152,273 | 19.7 | 19.2-20.2 | 11.0 | 10.5-11.5 | 2.06 | 1.97-2.16 |
| Renal failure | 23,036 | 116,090 | 15.0 | 14.5-15.6 | 8.2 | 7.8-8.7 | 1.38 | 1.30-1.45 |
| Solid tumor without metastasis | 7,487 | 37,893 | 4.9 | 4.7-5.1 | 7.6 | 6.9-8.2 | 1.34 | 1.23-1.47 |
| Peptic ulcer disease excluding bleeding | 73 | 371 | 0 | 0-0.1 | - | - | - | - |
| Valvular disease | 6,804 | 34,318 | 4.4 | 4.2-4.7 | 7.5 | 6.8-8.3 | 0.86 | 0.79-0.94 |
| Weight loss | 14,080 | 70,584 | 9.1 | 8.6-9.7 | 13.1 | 12.4-13.8 | 1.39 | 1.32-1.47 |
a. Referent groups were adult hospitalizations without corresponding comorbidity (suppressed). b. Subgroup with comorbidity are shown (subgroups without comorbidity: n = 153,124 - n for subgroup with corresponding comorbidity). c. 95% confidence interval. d. Rate ratios from log-linear regression model with backward elimination procedure that adjusted for age (continuous), sex, race/ethnicity, days of hospital stay (continuous), primary expected payer, major operating room procedure, and all comorbidities excluding “acquired immune deficiency syndrome,” “arthritis (rheumatoid)/collagen vascular diseases,” “diabetes uncomplicated,” “Other neurological disorders,” and “peptic ulcer disease excluding bleeding.” e. Variable not in the final regression model. f. Comorbidities significantly and positively associated with in-hospital death are bolded.