Table 1.
Clinical characterizations and circulating inflammatory markers between large- and small vessel disease in patients with acute ischemic stroke.
| LAA (n=52) |
SAO (n=47) |
P value | |
|---|---|---|---|
| Race (Asian) | 100% | 100% | 1 |
| Ethnicity (Han) | 100% | 100% | 1 |
| Age (years) | 64(57,77) | 69(57,78) | 0.42 |
| Gender(M/F) | 32/20 | 29/18 | 0.87 |
| Hypertension | 84.6% | 78.7% | 0.12 |
| Diabetes | 19.23% | 19.14% | 0.75 |
| Dyslipidemia | 53.84% | 51.03% | 0.79 |
| NIHSS | 5(3,10) | 2(1,3) | 0.001 |
| Infarct volume | 3.97(1.3,27.80) | 0.45(0.16,1.82) | 0.001 |
| WBC (×109/L) | 7.30(5.80,8.10) | 6.60(5.70,8.13) | 0.24 |
| Lymphocyte (×109/L) | 1.79(1.20,2.18) | 1.70(1.32,2.19) | 0.80 |
| Monocyte (×109/L) | 0.47(0.39,0.61) | 0.53(0.42,0.70) | 0.16 |
| Cholesterol (mmol/L) | 4.81(4.14,5.60) | 4.78(4.10,5.67) | 0.80 |
| Triglyceride (mmol/L) | 1.79(1.19,2.16) | 1.50(1.03,2.07) | 0.24 |
| LDL (mmol/L) | 2.93 (2.29, 3.55) | 3.03 (2.38, 3.65) | 0.67 |
| HDL (mmol/L) | 1.05 (0.90, 1.19) | 1.14 (0.95, 1.33) | 0.08 |
| ApoA (mmol/L) | 1.21 (1.05, 1.40) | 1.17 (1.04, 1.46) | 0.72 |
| ApoB (mmol/L) | 1.06 (0.84, 1.23) | 1.03 (0.86, 1.16) | 0.93 |
| Lp(a) (mmol/L) | 0.15 (0.07, 0.26) | 0.15 (0.10, 0.26) | 0.72 |
| CD40L (pg/ML) | 139.66 (91.29, 238.46) | 139.30 (90.35, 269.80) | 0.74 |
| IFN-γ (pg/ML) | 0 (0, 0) | 0 (0, 0) | 0.61 |
| IL-1α (pg/ML) | 0 (0, 0) | 0 (0, 0) | 1 |
| IL-1β (pg/ML) | 0 (0, 0) | 0 (0, 0) | 1 |
| IL-6 (pg/ML) | 0.65 (0.20, 1.95) | 0.65 (0.00, 1.45) | 0.55 |
| IL-8 (pg/ML) | 5.03 (3.50, 7.09) | 4.20 (3.26, 6.85) | 0.45 |
| IL-17 (pg/ML) | 0 (0, 0) | 0 (0, 0) | 0.61 |
| TNFα (pg/ML) | 6.93 (4.48, 9.34) | 6.10 (4.56, 8.70) | 0.46 |
| Fg (g/L) | 3.25 (2.53, 4.08) | 3.10 (2.70, 3.60) | 0.40 |
| D-dimer (mg/L) | 0.30 (0.16, 0.55) | 0.27 (0.19, 0.51) | 0.83 |
| CRP (mg/L) | 6.20 (3.80,11.50) | 3.35 (1.75, 6.10) | 0.01 |