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Myometrial tumors in the lungs of uterine-specific Tsc2 KO mice. (A) Lung tumors (arrows) were found in 75% (6/8) of 31 week and older uterine-specific Tsc2 KO mice. H&E staining showed leiomyoma-like appearance. (B) Immunoblots of uterine and a lung tumor from a representative mouse demonstrated lack of Tsc2 protein. (C) Immunohistochemical staining demonstrated that the lung tumors were PR, ERα, SMAα, and phosphorylated S6 positive, but negative for the lung marker Nkx2.1.
