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. 2013 Aug 27;7:136. doi: 10.3389/fncel.2013.00136

FIGURE 2.

FIGURE 2

Neuronal activity influences miRNA expression through multiple mechanisms. Activity-dependent transcription induces miRNA production through Mef2 and Creb while Lin28a increases expression through an uncertain combination of transcription-dependent and -independent mechanisms. Increased levels of Lin28a lead to destabilization of pre-let-7 transcripts through poly-uridynylation. Activity also promotes accelerated miRNA turnover through an additional unknown mechanism(s). Activity-dependent phosphorylation of TRBP stabilizes Dicer, leading to increased mature miRNA production. NMDAR-activation promotes the ubiquitinylation of MOV10, a component of RISC, which may lead to decreased levels of mature-miRNA loaded RISC. See text for details.