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Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Relation of predicted CLint, in vitro and CLint, in vivo for hepatocytes (a) and microsomes (b). Dashed lines represent unity, fitted power functions and (a) upper and lower limits of bias correction for hepatocytes. From: Hallifax et al. 2010