Table 7.
Commercially available bioengineered liver models
| Company | Platform | Dimensionality | Mimicked biomimetic cues |
|---|---|---|---|
| Hepregen | Micropatterned liver cells colonies surrounded by stromal cells | 2D | Hepatocyte–stromal cells interaction |
| Miromatrix | Liver constructs based on whole-organ decellularization–recellularization | 3D | Vascularization, liver-specific ECM, hepatocyte–stromal cells interaction |
| MIT (Griffith laboratory) | Microfluidic system. | 3D | Physiological shear stress. |
| CellAsic | Microfluidic system | 2D | Plasma perfusion, endothelial-like barrier between liver cell layers (artificial sinusoids) |
| Hurel | Microfluidic system | 2D | Plasma perfusion, liver architecture. |
| RegeneMed | Porous nylon 3D interweaving nanofiber scaffold, 96-well format | 3D | 3D hepatocyte–stromal cells interaction |
| InSphero | Spheroid model | 3D | 3D hepatocyte–Kupffer cell–endothelial cell interactions |